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I'm looking to start a new biotech venture. In creating my financial plan I need to know how much it costs to set up a lab. I can get leasing information but there is little information on actual costs for stocking the lab. Thank you for your help.
Answer
It costs a lot. Maybe about $2M? The average biotech lab has at LEAST a micro, analytical and top loader balances, ultrasonicator bath, HPLC with varying detectors (UV, PDA, MS), HPLC columns, a chromatography aquisition server(ie Empower), validated sample storage chambers at all the ICH conditions (5C, 25C/60%RH, 30C/65% RH, 40C/75%RH), Karl Fisher, Fume hood, lab benches, Wet and dry chemicals, various glassware (pipettes, beakers, volumetric flasks, graduated cylinders etc), Dissolution bath if you are planning on doing oral dosage units (inhaled pharmaceutical and sterile injectables require a lot of other specialized equipment), a stand alone UV-Vis, and maybe a GC.
Here is the breakdown of what goes into setting up a piece of equipment: I'll use an analytical balance as an example: The balance by itself costs about $5,000, then you need to buy calibration weights which could cost an upwards of another $1000, you will need to pay to have the balance Installation, Operation and Performance Qualified (IQ/OQ/PQ) you may be able to save money if you can do the PQ on your own. Then you will have to purchase a service contract to do regular calibrations on the balance as required by FDA guidelines. That would cost you around $500 per calibration. The weights will have to be sent off and qualified by NIST as well on a regular basis. You will also need to ensure there is absolutely no chance of vibration on the surface in which the balance sits....most labs have their balances sitting on solid marble tables to remedy this. Total cost for the one balance is around $25K for everything. Then all the other equipment you buy will go through similar processes (purchase, IQ/OQ/PQ, service contract etc)
Now lets talk about compliance. If your lab is not compliant you might as well hang it up. If you want to be successful you need to get registered with both the FDA and the DEA.....which isn't cheap. You would need to hire a consultant to help with your SOPs, policies and methods. Again, if your lab is out of compliance and you are doing work....you could end up in jail. You will need to hire an experienced QA person to review your work.
Don't forget standards, which depending on what type of material you are working on....USP standards can cost as much as $1000 for 20mg. Sometimes Sigma Aldrich has a better price, but at a lower standard of quality.
I cant even tally up the total costs in my head, but I would decide first of all what type of work you are going to do, look up vendors (Waters, Agilent, Phenomenex, Mettler Toledo, Fisher, USP, Distek) and get quotes. Then contact the FDA and DEA to see about registration costs. And make sure you hire a GOOD consultant.
It costs a lot. Maybe about $2M? The average biotech lab has at LEAST a micro, analytical and top loader balances, ultrasonicator bath, HPLC with varying detectors (UV, PDA, MS), HPLC columns, a chromatography aquisition server(ie Empower), validated sample storage chambers at all the ICH conditions (5C, 25C/60%RH, 30C/65% RH, 40C/75%RH), Karl Fisher, Fume hood, lab benches, Wet and dry chemicals, various glassware (pipettes, beakers, volumetric flasks, graduated cylinders etc), Dissolution bath if you are planning on doing oral dosage units (inhaled pharmaceutical and sterile injectables require a lot of other specialized equipment), a stand alone UV-Vis, and maybe a GC.
Here is the breakdown of what goes into setting up a piece of equipment: I'll use an analytical balance as an example: The balance by itself costs about $5,000, then you need to buy calibration weights which could cost an upwards of another $1000, you will need to pay to have the balance Installation, Operation and Performance Qualified (IQ/OQ/PQ) you may be able to save money if you can do the PQ on your own. Then you will have to purchase a service contract to do regular calibrations on the balance as required by FDA guidelines. That would cost you around $500 per calibration. The weights will have to be sent off and qualified by NIST as well on a regular basis. You will also need to ensure there is absolutely no chance of vibration on the surface in which the balance sits....most labs have their balances sitting on solid marble tables to remedy this. Total cost for the one balance is around $25K for everything. Then all the other equipment you buy will go through similar processes (purchase, IQ/OQ/PQ, service contract etc)
Now lets talk about compliance. If your lab is not compliant you might as well hang it up. If you want to be successful you need to get registered with both the FDA and the DEA.....which isn't cheap. You would need to hire a consultant to help with your SOPs, policies and methods. Again, if your lab is out of compliance and you are doing work....you could end up in jail. You will need to hire an experienced QA person to review your work.
Don't forget standards, which depending on what type of material you are working on....USP standards can cost as much as $1000 for 20mg. Sometimes Sigma Aldrich has a better price, but at a lower standard of quality.
I cant even tally up the total costs in my head, but I would decide first of all what type of work you are going to do, look up vendors (Waters, Agilent, Phenomenex, Mettler Toledo, Fisher, USP, Distek) and get quotes. Then contact the FDA and DEA to see about registration costs. And make sure you hire a GOOD consultant.
What's a good, low cost way to get your construction level up on runescape?
Nicholas
Ok, my construction level is 53, what's the best way to get it up with out spending much more than 500k?
Answer
Sadly, it's not possible. I don't know what level you are trying to get to, but 500k is not enough :). Since you are already a pretty high level, the best is to build the workroom and workbench, if you haven't done so, and make oak tables. They use 6 planks at a time, very fast way to level up. If you'd like to think of time wise, hiring a butler north of Ardougne will take the logs to the timber yard for you, and when you have a lot piled up in your bank, you can sit at the work bench and send him to get more, while you drop your made objects onto the floor. It's very fast, although the butler will cost you probably 15k, depending on how long you want to use him and if he's going to the lumber year or just getting materials from the bank. Hope this helps :) Stay away from teak and mahogany price wise. It's very expesnive and not really worth the xp.
Sadly, it's not possible. I don't know what level you are trying to get to, but 500k is not enough :). Since you are already a pretty high level, the best is to build the workroom and workbench, if you haven't done so, and make oak tables. They use 6 planks at a time, very fast way to level up. If you'd like to think of time wise, hiring a butler north of Ardougne will take the logs to the timber yard for you, and when you have a lot piled up in your bank, you can sit at the work bench and send him to get more, while you drop your made objects onto the floor. It's very fast, although the butler will cost you probably 15k, depending on how long you want to use him and if he's going to the lumber year or just getting materials from the bank. Hope this helps :) Stay away from teak and mahogany price wise. It's very expesnive and not really worth the xp.
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Title Post: How much does it cost to stock a standard biochemistry lab?
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Rating: 96% based on 9658 ratings. 4,4 user reviews.
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